Antihelminthic effects of active substances moxidectin and praziquantel

Abstract

A.P. Paliy, N.V. Sumakova, I.A. Biben, V.V. Zazharskyi, D.V. Sliusarenko, I.D. Yevtushenko, O.V. Pavlichenko, Y.M. Livoshchenko, V.S. Bulavina, A.P. Palii

A comprehensive approach to conducting preventive and therapeutic measures involves studying the resistance of parasites to anthelmintic drugs synthesis of new preparations of a wide range of action. The purpose of the study was to compare the effectiveness of the effect of antiparasitic drugs of various dosage forms with the exact content of agents on dogs and cats. The surveyed dogs and cats that come to the shelter for pets were diagnosed by mono- and mixing of helminthiasis. The eggs of helminths (Dipylidium caninum, Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Uncinaria stenocephala and Dipylidium caninum, Toxocara mystax, Toxascaris leonina, and Trichuris vulpis) induced in the samples of feces from sick dogs and cats, respectively. There is a contamination of dogs and cats with microfilariae. We proved that the most contaminated eggs of helminth objects in indoor premises are gender and inventory. Antiparasitic agents containing moxidectin and praziquantel there are effective anthelminthic during cestodes, nematodes, trematodes, and mixed invasions of dogs and cats, regardless of the form of release (tablets, suspension) in a dose corresponding to the therapeutic concentration of 0.25 mg moxidectin and 5 mg of praziquantel on 1 kg body weight of the animal.

Keywords: invasion, moxidectin, praziquantel, dogs, cats, rooms.
 

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