Assessment of the level of sex hormones in the blood of domestic animals when using contraceptives

Abstract

A.P. Paliy, E.A. Dotsenko, L.M. Kovalenko, A.V. Telyatnikov, K.O. Rodionova, I.V. Nikolenko, O.V. Matsenko, K.A. inyagovskay, M.V. Kazakov, A.P. Palii

Many methods and tools are used to control sexual function in dogs and cats. However, there are many unresolved issues related to the diagnosis of changes in the reproductive system of animals, multiplicity, dosage and method of contraception, development of innovative methods of reproductive suppression. The study aimed to scientifically substantiate the effectiveness of hormonal drugs with the active substance megestrol acetate in cats and dogs of different breeds and genders. The experiments used two hormonal drugs containing megestrol acetate 5 mg each. Quantitative determination of the concentration of sex hormones in the blood of animals using hormonal drugs was carried out following current guidelines and legal acts. Experiments have shown that the studied contraceptives are well tolerated by cats and dogs and do not cause side effects and changes in the clinical condition of animals. We found that the studied hormonal drugs, when administered orally, cause a probable decrease (p<0.001) in progesterone, follicle-stimulating, and luteinizing hormones in female cats and dogs, as well as a probable decrease (p<0.001) in testosterone levels in cats and male dogs compared to indicators in control groups. We determined that the studied hormonal drugs exhibit antiestrogenic and anovulatory effects when used following the recommended regimens.

Keywords: megestrol acetate, dogs, cats, follicle-stimulating hormone, luteinizing hormone, progesterone, testosterone, blood serum.
 

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