Enzyme therapy is a highly effective and environmentally safe method of treating lacerated wounds in dogs


L. O. Kovalyova, O. A. Dubova*, P. V. Kovalyov, V. V. Karpyuk and D. V. Sliusarenko

The results of the wound-healing effect of Iruxol® cream in lacerated and crushed wounds of the distal extremities of dogs studies are presented. The injuries were caused by animals falling into arc traps. Such wounds are severe, with maximum tissue damage in the zone of influence of the traumatic factor. It was found that lacerated and crushed wounds are characterized by uneven, swollen, and necrotic edges, crushed tissues of muscles and tendon structures, scalping, and in some cases, bone fractures. The general clinical condition was assessed as intoxication-septic, which is accompanied by traumatic shock, sepsis, and a multi-organ inflammatory reaction. Hypochromic anemia, leukocytosis, accelerated erythrocyte sedimentation rate, left shift of the nucleus indicates intoxication syndrome, and a systemic inflammatory reaction. Lymphocytosis with monocytosis indicates the body's immune system's stimulation to fight destroyed tissues and sepsis, which develops as a complication of a lacerated and crushed wound. Thrombocytopenia is one of the diagnostic criteria for developing disseminated blood clotting syndrome. Together, these complications constitute the pathogenetic axis of shock. The development of vital organs' insufficiency is represented by hepatic and renal insufficiency as the results of intoxication-septic and shock conditions. This clinical status requires infusion and antibiotic therapy. After mechanical cleaning of the wound, the use of Iruxol® cream based on peptidases for 21 days contributes to the formation of full-fledged structural components of scar tissue in the shortest possible time. The drug's main components that provide its effect are the enzymes collagenase, clostridiopeptidase A, and other peptidases. Enzymes break down the destroyed elements of injured tissues by their proteolysis. The wound is cleaned, and the best conditions are created to form granulation tissue and wound healing. Released under enzymes' action, oxyproline from collagen helps restore the protein components of damaged tissues. These substances are completely bioavailable. Their use is not only therapeutically effective but also environmentally safe. The need for complex treatment of lacerated and crushed wounds, which contributes to the restoration of the general clinical condition and adequate healing of a severe wound, is shown.

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