Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl) methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide
Abstract
A.S. Hotsulia, V.V. Zazharskyi, P.O. Davydenko, O.M. Kulishenko, V.V. Parchenko, I.V. Bushuieva, N.M. Grynchyshyn, B.V. Gutyj*, N.V. Magrelo, V.Y. Prysyaznyuk, H.V. Sus and U.M. Vus
The results of morpho-biochemical studies of tuberculosis inflammation in rabbits in an experimental model with comparative isoniazid treatment and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. It was found that subcutaneous administration of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide at a dose of 10 mg/kg body weight leads to the absence of specific and nonspecific manifestations of inflammation in the lungs, liver, kidneys and spleen. The calculated value of the drug indicates a high degree of safety N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotino-hydrazide and its prospects for veterinary practice as an effective and safe tuberculocidal drug