Features of experimental modeling of tuberculosis in guinea pig with the participation of N'-(2-(5-((thephylline-7' yl)methyl)-4-R-1,2,4-triazole- ylthio)acethyl)isonicotinohydrazide
Abstract
Ð.S. Gotsulya, V.V. Zazhzharskiy, P.O. Davidenko, N.M. Zazhzharskaya, O.M. Kulishenko, O.I. Panasenko, B.V. Gutyj, O.B. Pryima, I.Y. Mazur, V.V. Pritsak, U.R. Drachuk, A.G. Sobolta, M.B. Riy
In this study, no toxic effects were detected after single subcutaneous injection of 40 mg/kg tadpoles. The results of macro- and microscopic examination of the internal organs 14 days after single subcutaneous administration of N'-(2-(5-((thephylline-7'-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acethyl)isonicotino-hydrazide (GKP-305) at a dose of 20, 40 mg/kg showed the absence of any anatomical and morphological abnormalities in the tissue structures of the tentacles. The calculated value of the drug indicates a high degree of safety GKP-305 and its prospects for veterinary practice as an effective and safe tuberculocidal drug.
Key words: Tuberculosis, 1,2,4-triazole, modeling, guinea pig
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