Hematological Indices Of Rats During The First Hour After Chlorpyrifos Exposure


V. P. Rosalovsky

We studied the effects of acute chlorpyrifos intoxication on the erythrocytes resistance to acid hemolysis and certain hematological parameters (number of erythrocytes, leucocytes, monocytes, lymphocytes, granulocytes, and trombocytes, hemoglobin content, hematocrit, trombocrit, and platelet indices). Acute exposure to 50 mg/kg CPF leads to a decrease in the resistance of main erythrocytes pool to acid hemolysis at 15 minutes after exposure. The number of leucocytes increased by 21,9%, of erythrocytes – by 9,0%, hemoglobin content – by 6,3%, compared to controls, at 15 minutes after exposure. The number of trombocytes decreased by 21,6% at 15 min, by 26,2% at 30 min, by 53,3% at 45 min, and by 56,0% at 60 min after exposure, compared to control means.

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