Increasing The Efficiency Of Some Antibiotics On Penetrating Bacteria Cell Membrane

Abstract

Sara Shahriari, Majid Monajjemi, Karim Zare

By this work, it has been concluded that through halogenated functionalizing of Sulfonamide, Triclosan, Baxdela, Ticarcillin, Ampicillin, and Clavulanic acid we are able to control the treatment of those antibiotics against Gram-positive or negative bacteria of various ecologies. The efficiency of Sulfonamide, Triclosan, Baxdela, Ticarcillin, Ampicillin and Clavulanic acid in viewpoint of NMR shielding and S-NICS methods have been studied as a drug delivery approach. We exhibit some halogenated compounds of those antibiotics, specific chemical derived produced, which are primarily against “gram positive” bacteria (due to higher percentage of “peptidoglycan protein” in the cell membranes). Since Gram-positive bacteria which made of peptidoglycan has a very thick cell wall, some of the antibiotics can penetrate gram (+) and some others cannot. In this work, a list of antibiotics and their halogenated deviated have been set-upped due to the Gram-positive bacteria. A list of halogenated compounds had been reported based on mechanism of the S-layer with two different attachments; for gram (+) it is attached to the peptidoglycan and for gram (-) directly to the outer layers of bacteria.

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