Influence of iron (IV) clathrochelate complexon quail blood parameters and weight characteristics


V.B. Dukhnitsky, I.M. Derkach, S.S. Derkach, I.O. Fritsky, M.O. Plutenko

We studied the chronic toxicity of the compounds of Iron(iv). We monitored the dynamics of the body weight, relative weight
coefficients of the internal organs, the content of the hemoglobin, the morphological parameters of blood, and biochemical
parameters of serum of blood of quails after use of Iron(IV) clathrochelate complexes at the doses 1/10 and 1/5 DL50 them for 30
days. Daily drinking of quails of experimental groups of solution of Iron(IV) clathrochelate complexes3 at the doses 76.43 and
152.86 mg/kg of body weight caused the reduction of body weight by 3 and 5% respectively on the thirtieth day. A tendency to
increase the relative weight of the kidneys and to decrease the relative weight of the liver, heart and spleen showed an excessive
load of Iron(IV) clathrochelate complexes on the internal organs of quails. Hemoglobin in the blood of the quails of the experimental
groups was less by 2-34% (P<0.05) than the control indicator but the indicator of the number of erythrocytes in the quails of the
control and experimental groups for 30 days was within the physiological values. The use of Iron(IV) clathrochelate complexes
caused the development of hypoproteinemia, hypoalbuminemia, and short-term hypoglycemia in the serum of the blood of the
quails of the experimental groups. Changes in an activity of alanine aminotransferase and aspartate aminotransferase for 30 days
were not expressed, but the activity of alkaline phosphatase was significantly higher compared to the control indicators during the
experimental period. Drinking the solution of Iron(IV) clathrochelate complexes caused hypercreatinemia and hyperuricemia, which
indicates a decrease in the filtration capacity of the kidney glomeruli. We have seen an increase in the levels total Calcium and
inorganic Phosphorus.
Key words: Toxicity; Hexahydrazide clathrochelate; Body weight; Morphology; Biochemistry; Quail
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