Level Of Lipid Peroxidation Products In The Blood Of Rats Under The Influence Of Oxidative Stress And Under The Action Of Liposomal Preparation Of "butaselmevit"

Abstract

T. V. Martyshuk, B. V. Gutyj, O. I. Vishchur

The article presents the results of investigation of the impact of stress on oxidative intensity of lipid per oxidation. It was proved that intramuscular injection of 50% solution of tetrachloromethane at a dose of 0.25 mL per 100 g of rat body causes the activation of free radical lipid oxidation with excessive accumulation of intermediate and final products of lipid peroxidation. Our results indicate that the development of oxidative stress leads to the significant acceleration of the formation and accumulation of lipid hydroperoxides and malondialdehyde (MDA) in plasma of rats. We registered the highest level of lipid hydroperoxides in rat blood plasma under oxidative stress on the second day of the experiment; it was 0.843 un/mL, whereas this index was 0.245 un/mL in the control group. We also revealed that the content of malondialdehyde was the highest in the experimental group on the fifth day of the experiment; it was almost 2 times higher than in control group. We could recommend to apply the liposomal drug "Butaselmevit" which contains butafosfan, selenium, methionine, milk thistle, and vitamins for the inhibition of lipid peroxidation under the development of oxidative stress. It was proved that the parenteral injection of liposomal drug "Butaselmevit" to the rats for the development of oxidative stress leads to a reduction of peroxidation products level in their plasma. We revealed that the level of intermediate and final products of lipid peroxidation in the blood of rats that were used liposomal drug reached normal physiological values on the 14 day of the experiment. Our results suggested that the new liposomal drug "Butaselmevit" has definite antioxidant properties

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