Lipid metabolism and dyslipidemia incidence among urban residents


E.A. Sharlaeva, R.I. Vorobyev, E.N. Vorobyeva, G.G. Sokolovа, I.V. Bobina

The lipid metabolism indicators were analyzed: total cholesterol (TC), cholesterol of low density lipoprotein (LDL cholesterol), high density lipoprotein cholesterol (HDL cholesterol), triglycerides (TG) and atherogenic index (IA) in different age groups of men and females in Barnaul Altai region. It was shown that in the examined men and females the levels of total cholesterol and LDL cholesterol exceeded the norm; levels of HDL cholesterol and TG in both sex groups corresponded to the reference values. With age the level of TC and LDL cholesterol in the serum increases, respectively, and the AI. The TG content does not undergo significant changes, and the HDL cholesterol level tends to decrease. Data from biochemical blood tests were used to classify lipid spectrum disorders. Atherogenic dyslipidemia was found in 69.9 ± 2.2% of cases, and in 17.2 ± 1.8%-combined dyslipidemia.

Keywords: Lipid metabolism; dyslipidemia; atherogenic index; cardiovascular diseases

Chazov, E. I. (2008). Puti snizheniya smertnosti ot serdechno-sosudistykh. Terapevticheskij arhiv, 8, 11-16 (in Russian).
Erem, C., Hacihasanoglu, A., Deger, O., Kocak, M., & Topbas, M. (2008). Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine Journal, 34(1-3), 36-51. doi: 10.1007/s12020-008-9100-z.
Ezhov M. V., Sergienko I. V., & Aronov D. M. (2017). Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis Russian recommendations VI revision. Atherosclerosis and dyslipidemia, 3, 5-22 (in Russian).
Fredrickson, D. S., Levil, R. L., & Lee, R. S. (1967). Fat transport in lipoproteins-An integration approach to mechanisms and disorders. New England Journal of Medicine, 276, 273-281.
Grundy, S. M., Cleeman, J. I., & Merz, C. N. (2004). Coordinating Committee of the National Cholesterol Education Program. Implication of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Journal Of The American College Of Cardiology, 44, 720-732.
Helkin, A., Stein J. J., Lin, S., Siddiqui, S., Maier, K. G., & Gahtan, V. (2016). Dyslipidemia Part 1-Review of Lipid Metabolism and Vascular Cell Physiology. Vascular & Endovascular Surgery, 50(2), 107-18. doi: 10.1177/1538574416628654.
Iso, H. (1989). Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. New England Journal of Medicine, 320, 904-910.
John, S. (2000). Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences. Journal of Hypertension, 18, 363-374.
Joshi, S. R., Anjana, R. M., Deepa, M., Pradeepa, R., Bhansali, A., & Dhandania, V. K., Prashant, P. J., Ranjit, U., Elangovan, N., Radhakrishnan, S., Sri, V. M., Paturi, V. R., Ashok, K. D., Tanvir, K., Deepak, K. S., & Viswanathan, M. (2014). Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. Public Library of Science (PLOS), 9(5), e96808. doi: 10.1371/journal.pone.0096808.
Lindenstrom, E. V. (1994). Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study. BMJ, 309, 11-15.
Molani, Gol R., Rafraf, M., & Asghari, J. M. (2018). Evaluation of cardiovascular risk factors in females referring to health centers in Tabriz, Iran, 2017. Health Promot Perspect, 8(4), 315-322. doi: 10.15171/hpp.2018.45.
Oganov, R. G., & Maslennikova, G. Ya. (2000). Problemy serdechno-sosudistykh zabolevaniy v Rossiyskoy Federatsii i vozmozhnosti ikh resheniya. Kardiologiya, 4, 216 (in Russian).
Okamura, T. (2010). Dyslipidemia and cardiovascular disease: a series of epidemiologic studies in Japanese populations. Journal of Epidemiology, 20(4), 259-65.
Ross, R., Glomset, J. A. (2006). Dyslipidemia and the Risk of Incident Hypertension in Men. Journal of Hypertension, 47, 45-50.
Tabatabaei-Malazy, O., Qorbani, M., Samavat, T., Sharifi, F., Larijani, B., & Fakhrzadeh, H. (2014). Prevalence of Dyslipidemia in Iran: A Systematic Review and Meta-analysis Study. International Journal of Preventive Medicine, 5(4), 373-93.
Tot, P. P., & Meki, K. K. (2010). Narusheniya lipidnogo obmena. Moscow. GEOTAR-Media (in Russian).
Tuomikoski, P., Lyytinen, H., Korhonen, P., Hoti, F., Vattulainen, P., Gissler, M., Ylikorkala, O., & Mikkola, T. S. (2014). Coronary heart disease mortality and hormone therapy before and after the Females's Health Initiative. Obstetrics & Gynecology, 124(5), 947-953.
Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., & Lisheng, L. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet, 364, 937-952.

Share this article