Study of acute and chronic toxicity of ginkgo biloba samples
T. I. Fotina, H. A. Fotina, I. M. Kovalenko, R. A. Yaroshchuk, A. I. Fotin, S. M. Nazarenko, O. V. Fotin
The article presents the results of acute and chronic toxicity of Ginkgo Biloba samples. In assessing the general condition of animals after 30 minutes and 1 hour single extract administration at doses of 1,000, 2,500 and 5,000 mg/kg, it has been established that the motility and mobility of mice were reduced. After third hour of observation these phenomena was not observed. Other signs of intoxication, in particular the central and autonomic nervous system (lateral position, reduction of muscle tone, violation of coordination of movements, blepharoptosis, hyperalsalivation, etc.) were not noted. Based on the results of the studies, Ginkgo Biloba extract with subcutaneous administration to white mice for 14 days in a therapeutic dose did not cause significant changes in the general condition, body weight, morphological and biochemical blood parameters.