Study of the toxicity and effectiveness of an antiparasitic agent based on tinidazole and fenbendazole
A.P. Paliy, N.V. Sumakova, A.V. Telyatnikov, I.O. Zhukova, O.I. Kasianenko, O.I. Shkromada, Yu.O. Suprun, L.V. Plyuta, I.D. Yevtushenko, L.V. Kovalenko, E.A. Dotsenko, A.P. Palii
The development of new import-substituting highly effective and environmentally friendly complex antiparasitic drugs and their implementation in a scientifically grounded system of measures to combat the causative agents of the main invasive diseases of farm animals and poultry remains an urgent task of veterinary medicine. Based on the results of studies of anthelmintic and antiprotozoal action of agents on exogenous forms of parasites, an experimental form of a complex antiparasitic agent "Tinidafen" was created and investigated. An experimental sample in the form of a powder was created on the basis of two active substances – tinidazole and fenbendazole with the addition of excipients (talc, starch). It has been established that the LD50 of "Tinidafen" for white rats with a single dose is 2564.36±349.13 mg/kg. The therapeutic dose of "Tinidafen" for rabbits is 7.5 g per 10 kg of live body weight. The extensefectevity of "Tinidafen" is 99.5% for helminths and 98.7% for eimeria. After administered orally of the agent, helminth eggs in the feces of infested animals were not registered from day 3, and the release of eimeria oocysts was observed until day 5 of the experiment.
Key words: mixinvasions, tinidazole, fenbendazole, "Tinidafen", toxicity, helminth eggs, eimeria oocysts