Bactericidal properties of the geochid preparation

Abstract

V.L. Kovalenko, V.P. Lyasota, Y.O. Balatskiy, N.V. Bukalov, N.M. Bogatko, O.O. Petrenko, L.S. Onishchenko, S.A. Tkachuk

Is an acute problem with insuffi cient regulation of hazardous components disinfectants and regulations of the European Union. This makes the development of methodological approaches to rapid normalization of disinfectants and the need to prevent their harmful effects on human health during the application according to the purpose. Ensuring the deployment procedure of state sanitary and epidemiological expertise disinfectants to scientifically based risk analysis. Remains topical scientific substantiation of monitoring programs for sensitivity to infectious agents and disinfectants containing active substances in the environment. "Heotsyd" - a liquid concentrate transparent, light-yellow foam when shaking, has little odor, soluble in water. Working solutions anticorrosion and do not damage the painted surface of building structures, plastic and fabric. Polyhexamethyleneguanidine hydrochloride, a substance that has strong antibacterial properties. Synthetic pyrethroids - deltametryn during processing ensures evaporation material preparation for further cooling in air condensation aerosol is formed. Aerosol active substance deposited on technological equipment, walls, buildings, skin of animals and birds, penetrating through the respiratory system and digestive system of insects, causing their death and thus has required insecticidal effect. Note that deltametryn provides long residual effect on the treated surface, which gives it an edge over other insecticides. The drug is a disinfectant, it is inherent in washing performance, it can be used for preventive and forced disinfection of livestock, poultry, commercial and laboratory space, as well as disinfection of tools and equipment, railway cars, vehicles, objects of veterinary supervision. The drug is bactericidal, virucidal, fungicidal and insecticidal properties. Studied bactericidal disinfectant complex drug "Heotsyd" (0.5% solution) based in Polyhexamethyleneguanidine hydrochloride (PHMG-GC), benzalkonium chloride and deltametrynu. It is established that the presence of protein bactericidal action with respect to S. aureus is reduced to 0,69 times. The investigational drug is highly bactericidal, on S. aureus in 0.5% concentration. On the smooth surface of the tiles high bactericidal activity of the investigational product starts with a 0.3% concentration for 30 minutes of exposure. For the first time found that a new sanitizer "Heotsyd" 0.5% concentration for 30 minutes exposure has effective antibacterial properties that ensure complete destruction of atypical mycobacteria - Mycobacterium fortuitum). Comprehensive disinfectants "Heotsyd" is a promising drug as a disinfectant.

Keywords: Regulation; sanitary and epidemiological expertise disinfection; aerosol bactericidal; gram positive; hramponenhatyvna microflora "Heotsyd" test culture; virucidal; fungicidal; insecticidal; prevention; environmental; sanitary quality

References:
Apatenko, V.M. (2009). Infectious pathology and microbial revolution. Veterinary medicine: interagency thematic scientific collection. Kharkiv. 92, 36-37 (In Russian).
Ponomarenko, G.V., Kovalenko, V.L., Ponomarenko, O.V., Balackiy, Yu.O. (2017). Effects of microbicide based on lactic acid and metal nanoparticles on laboratory animals. Ukrainian Journal of Ecology, 7(4), 482-485, doi: 10.15421/2017_148.
Reis, C.Р., Neufeld, R.I., Ribeiro, A.J. (2006). Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems. Nanomedicine: Nanotechnology, Biology and Medicine, 2, 53-65. DOI: 10.1016/j.nano.2006.04.009.
Lakhtin, V.M. (2008). Nanotechnologies and perspectives of their application in medicine and biotechnology. Vestn Ross Akad Med Nauk, 4, 50-55 (In Russian).
Afanasyeva, V.V. (2010). Clinical and laboratory substantiation of the choice of the optimal concentration of polyhexamethylene guanidine hydrochloride for its use in the practice of surgical stomatology as an antiseptic. Russian Dental Journal, 6, 8-12 (In Russian).
Bezrukava, I.Yu., Nalyvayko, L.I., Nalyvayiko, I.M. (2008). Disinfectants in veterinary practice. Poultry breeding: Intervet. Thematic sciences. Kharkiv 61, 234 (In Ukrainian).
Oberdorster, G., Oberdorster, E., Oberdorster, J. (2005). Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles. Environmental Health Perspectives, 113(7), 823-839.
Otter, J.A., French, G.L. (2009). Survival of nosocomial bacteria and spores on surfaces and inactivation by hydrogen peroxide vapor. J Clin Microbiol, 47(1), 205-207. DOI:10.1128/JCM.02004-08
Boychuk, T.M., Andriychuk, N.Y., Vlasik, L.I. (2012). To the problem of toxicity evaluation of silver nanoparticles. Clinical and Experimental Pathology, 11(42), 151-157 (In Ukrainian).
Tahir, S., Mateen, B., Univerdi, S., KaraGoban, O., Zengin, M. (2009). Simple method to study the mechanism of thermal and nonthermal bactericidal action of microwave radiations on different bacterial species. Journal of Bacteriology Research l, 1(5), 058-063. Available from: http://www.academicjournals.org/JBR
Solodun, Y.V., Monakhova, Y.B., Kuballa, T., Samokhvalov, A.V., Rehm, J., Lachenmeie, D.W. (2011). Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks. Interdiscip Toxicol, 4(4), 198-205. Available from: www.intertox.sav.sk & www.versita.com/science/medicine/it/
White, G.C. (2010). Handbook of chlorination and alternative disinfectants. New York: John Wiley and Sons Inc., p. 1062.
Brilin, A.P., Boyko, A.V., Volkova, M.N. (2005). Characteristics of new generation disinfectants. Veterinary Science, 3, 10-12 (In Ukrainian).
Kovalenko, V.L., Balatsky, Yu.O., Lyasota, V.P., Rozumnuk, A.V., Kovalenko, L.I. (2014). Complex mycological study of a disinfectant. Veterinary Biotechnology Bulletin 25, 11-15 (In Ukrainian).
Kovalenko, V.L., Lyosota, V.P., Sinitsin, V.A. (2004). General methods of prevention through the use of complex disinfectants: Scientific manual. Nizhyn: Publisher P.E Lysenko, M.M, p. 408.
Yakubchak, O.M. (2010). Veterinary disinfection (instructions and guidance). Kyiv: Bioprom, p. 152 (In Ukrainian).
Method of determination of bacteriostatic and bactericidal concentration of antibacterial preparations by the method of serial dilutions. (2003). State Scientific-Control Institute of Veterinary Preparations and Feed Supplements: MV Kosenko. Kyiv, p. 6 (In Ukrainian).
 

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