The general reaction of dogs in the acute stage babesia invasion
Canine babesiosis is a parasitic blood disease manifested by fever, anemia, jaundice of the visible mucous membranes, and hemoglobinuria. Generalized damage to internal organs and corresponding systems for this pathology significantly complicates its course, requires constant monitoring of the functional state of the organism of sick animals. The paper summarizes six cases of babesiosis in dogs of the Labrador breed at the age of 3 to 5 years. Morphological and biochemical blood tests and clinical analysis of urine parameters, and microscopy of its sediment were carried out. In particular, we found that during the acute stage of babesiosis in sick dogs, characteristic changes in the morphological blood profile are leukopenia with a decrease in the number of stab neutrophils with the simultaneous compensatory manifestation of basophilia and monocytosis, as well as erythrocytopenia, hypochromia, thrombocytopenia against the background of a decrease in hematocrit and thrombocytopenia. The most pronounced changes in canine babesiosis relate to the aminotransferase activity of blood plasma, particularly the development of hyperenzymemia of aspartate aminotransferase and alanine aminotransferase, respectively, 5 and 3 times compared with the control. In addition, in sick animals, hypoproteinemia, hypoalbuminenia and hyperazotemia are noted, which indicates a violation of homeostasis and the predominance of catabolic processes in the cells of internal organs primarily the liver. We registered a pronounced brown color and turbidity of urine, erythrocyturia, hemoglobinuria, leukocyturia, and proteinuria, which indicates the simultaneous development of nephropathy in dogs with babesiosis. Regularities have been established regarding changes in morphological and biochemical parameters of blood and urine at an early stage of babesiosis, which is essential for elucidating the pathogenesis of this pathology, determining the features of functional changes in the body of sick dogs, and for developing new approaches in their diagnosis, prevention of complications and treatment of animals.