The influence of HamekoTox on the morphological and biochemical indices of laying hens blood in spontaneous fumonisin toxicosis


O.M. Brezvyn, Z.A. Guta, B.V. Gutyj, L.M. Fijalovych, V.I. Karpovskyi, V.L. Shnaider, T.V. Farionik, R.S. Dankovych, T.O. Lisovska, I.V. Bushuieva, V.V. Parchenko, N.V. Magrelo, N.M. Slobodjuk, N.V. Demus, Kh.Ya. Leskiv


The most practical methods of detoxication of mycotoxins in animals and poultry are based on damaged feed sorbents. The search aims to study the influence of HamecoTox on the morphological and biochemical indices of the blood of laying hens in spontaneous fumonisin toxicosis. Laying hens (ferrets, aged 78 weeks) of cross Highsex White, with an average live weight of 1.5 kg, were used in the experiment. Three groups were formed: I – a group of laying hens served as a control, in the experimental II, III, groups of poultry was characteristic clinical signs of fumonisin toxicosis. Experiment III (?2) was fed with HamecoTox feed for 21 days. In the research of morphological indices of the blood of laying hens under conditions of fumonisin toxicosis and with the use of HamecoTox on the 21st day of the experiment, an increase in the number of erythrocytes and hemoglobin content was found in comparison with sick poultry. The number of leukocytes in the blood of laying hens, which used HamekoTox, reached physiological values on the 21st day of the experiment. HametoTox contributed to the recovery of the protein-synthesizing function of the liver by reducing the negative influence of fumonisins. After the release of the organism from fumonisins, the action of toxins on the liver ends up, and the inflammatory processes disappear accordingly. Under conditions of spontaneous fumonisin toxicosis in poultry, the additional introduction of HamecoTox to laying hens during the 21st day contributed to the normalization of biochemical indices of the blood of experimental poultry. To prevent the fumonisin toxicosis, it is recommended to add HamekoTox feed additive at a dose of 4 kg/t of feed to mycotoxin-contaminated feed.

Key words: fumonisins, toxicosis, poultry, laying hens, HamekoTox, blood



Berezovskyi, A.V., Fotina, T.I., Dvorska, Yu.Ie., & Rozputnia, O.A. (2014). Suchasni detoksykanty mikotoksyniv: analiz vitchyznianoho rynku. Naukovyi visnyk veterynarnoi medytsyny, 13, 37–41. Available from: (in Ukrainian).

Brezvyn, O., Otchych, V., & Kotsiumbas, I. (2013). Kontrol mikotoksyniv u kormakh i yikh zneshkodzhennia. Visnyk Lvivskoho universytetu. Ser.: Biolohichna, 62, 242–249. URL: (in Ukrainian).

Brezvyn, O.M., Rudyk, G.V., & Guta, Z.A. (2018). Influence of HammecoTox and Zeolitis on morphological and biochemical indicators of rat's blood under conditions of experimental fumonisin toxicosis. Ukrainian Journal of Veterinary and Agricultural Sciences, 1(1), 23–29. doi: 10.32718/ujvas1-1.04

Fodor, J., Meyer, K., & Riedlberger, M. (2006). Distribution and elimination of fumonisin analogues in weaned piglets after oral administration of Fusarium verticillioides fungal culture. Food Additives & Contaminants. 23(5), 492–501.

Fravalo, P., Oswald, I.P., Salvat, G., Pinton, P., Postollec, G., Queguiner, M., Cariolet, R., Boilletot, E., Guerre, P., Tanguy, M., & Burel, C. (2013). Effect of Low Dose of Fumonisins on Pig Health: Immune Status, Intestinal Microbiota and Sensitivity to Salmonella. Toxins, 5(4), 841–864. doi: 10.3390/toxins5040841.

Grenier, B., Dohnal, I., Shanmugasundaram, R., Eicher, S.D., Selvaraj, R.K., Schatzmayr, G., & Applegate, T.J. (2016). Susceptibility of Broiler Chickens to Coccidiosis When Fed Subclinical Doses of Deoxynivalenol and Fumonisins-Special Emphasis on the Immunological Response and the Mycotoxin Interaction. Toxins, 8(8), 231 doi: 10.3390/toxins8080231.

Grynevych, N., Sliusarenko, A., Dyman, T., Sliusarenko, S., Gutyj, B., Kukhtyn, M., Hunchak, V., & Kushnir, V. (2018). Etiology and histopathological alterations in some body organs of juvenile rainbow trout Oncorhynchus mykiss (Walbaum, 1792) at nitrite poisoning. Ukrainian Journal of Ecology, 8(1), 402–408. doi: 10.15421/2018_228

Guerre, P. (2015). Fusariotoxins in Avian Species: Toxicokinetics, Metabolism and Persistence in Tissues. Toxins, 7(6), 2289–2305. doi: 10.3390/toxins7062289.

Guta, Z. (2016). The influence of fumonisin toxicity on morphological and biochemical blood parameters in rats. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 18, 2(66), 48–51. doi: 10.15421/nvlvet6611 (in Ukrainian).

Gutyj, B., Grymak, Y., Drach, M., Bilyk, O., Matsjuk, O., Magrelo, N., Zmiya, M., & Katsaraba, O. (2017). The impact of endogenous intoxication on biochemical indicators of blood of pregnant cows. Regulatory Mechanisms in Biosystems, 8(3), 438–443. doi: 10.15421/021768

Gutyj, B., Khariv, I., Binkevych, V., Binkevych, O., Levkivska, N., Levkivskyj, D., & Vavrysevich, Y. (2017). Research on acute and chronic toxity of the experimental drug ?mprolinsyl. Regul. Mech. Biosyst., 8(1), 41–45.

Gutyj, B., Martyshchuk, T., Bushueva, I., Semeniv, B., Parchenko, V., Kaplaushenko, A., Magrelo, N., Hirkovyy, A., Musiy, L., & Murska, S. (2017). Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to action of liposomal preparation. Regulatory Mechanisms in Biosystems, 8(2), 304–309. doi: 10.15421/021748.

Gutyj, B., Martyshchuk, T., Bushueva, I., Semeniv, B., Parchenko, V., Kaplaushenko, A., Magrelo, N., Hirkovyy, A., Musiy, L., & Murska, S. (2017). Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to action of liposomal preparation. Regulatory Mechanisms in Biosystems, 8(2), 304–309. doi:10.15421/021748

Gutyj, B., Nazaruk, N., Levkivska, A., Shcherbatyj, A., Sobolev, A., Vavrysevych, J., Hachak, Y., Bilyk, O., Vishchur, V., & Guta, Z. (2017). The influence of nitrate and cadmium load on protein and nitric metabolism in young cattle. Ukrainian Journal of Ecology, 7(2), 9–13

Gutyj, B., Paska, M., Levkivska, N., Pelenyo, R., Nazaruk, N., & Guta, Z. (2016). Study of acute and chronic toxicity of 'injectable mevesel' investigational drug. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University, 6(2), 174–180.

Gutyj, B., Stybel, V., Darmohray, L., Lavryshyn, Y., Turko, I., Hachak, Y., Shcherbatyy, A., Bushueva, I., Parchenko, V., Kaplaushenko, A., & Krushelnytska, O. (2017). Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load. Ukrainian Journal of Ecology, 7(4), 589–596

Hoister, O.S., Dziadevych, S.V., & Minchenko, O.H. (2013). Zastosuvannia suchasnykh biosensornykh tekhnolohii v ekotoksykolohichnomu monitorynhu deiakykh toksykantiv pryrodnoho (mikotoksyny) ta antropohennoho (pestytsydy) pokhodzhennia. Chastyna I. Mikotoksyny. Sensorna elektronika i mikrosystemni tekhnolohii, 10(3), 55. (in Ukrainian).

Kim, E.K., Shon, D.H., Chung, S.H., & Kim, Y.B. (2002). Survey for fumonisin B1 in Korean corn–based food products. Food Additives Contaminants, 19(5), 459–464.

Lesyk, Y., Ivanytska, A., Kovalchuk, I., Monastyrska, S., Hoivanovych, N., Gutyj, B., Zhelavskyi, M., Hulai, O., Midyk, S., Yakubchak, O., & Poltavchenko, T. (2020). Hematological parameters and content of lipids in tissues of the organism of rabbits according to the silicon connection. Ukrainian Journal of Ecology, 10(1), 30-36. doi: 10.15421/2020_5

Vasylyev, D., Priimenko, B., Aleksandrova, K., Mykhalchenko, Y., Gutyj, B., Mazur, I., Magrelo, N., Sus, H., Dashkovskyy, O., Vus, U., & Kamratska, O. (2021). Investigation of the acute toxicity of new xanthine xenobiotics with noticeable antioxidant activity. Ukrainian Journal of Ecology, 11 (1), 315-318. doi: 10.15421/2021_47

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