Separate indices of homeostasis and the balance of the prooxidant–oxidant system in sheep for fetoplacental insufficiency

Abstract

P.M. Skliarov, S.J. Fedorenko, S.V. Naumenko, O.V. Onyshhenko, A.M. Pasternak, K.O. Holda

Our research is aimed at solving one of the primary problems of sheep farming – receiving a viable lambs, as the level of neonatal mortality of lambs is 15% and above, which significantly reduces the profitability of the livestock industry. One of the reasons for this is the fetoplacental insufficiency, which causes the violation of antenatal development and, as a consequence, decline of the clinical condition and potential of development of newborns. Solving the problem of fetoplacental malnutrition is primarily due to issues of diagnosis and prevention, which are difficult even for humane medicine. In veterinary obstetrics this direction remains insufficiently investigated. There are only a few publications, especially for sheep, but they are devoted to the study of several other aspects of fetoplacental insufficiency. Fetoplacental malnutrition is a multifactorial pathology, but in livestock production, ecologically deficient factors and defective/unbalanced feeding are the leading ones, which negatively affect the structure and function of the fetoplacental complex in particular. In particular, the concentration of free radical oxyslides increases while simultaneously reducing the antioxidant defense of the organism. According to the results of studies of individual homeostasis and the balance of the prooxidant–antioxidant system, their differences in the sheep breed are clinically healthy, compared with the animals for fetoplacental insufficiency. The results obtained will be used by us in the further development of the method of objective diagnosis and the program of rational prevention of fetoplacental insufficiency in sheep.

Keywords: Viable lambs; Antenatal pathology; Diagnosis; Antioxidant defense; Fetoplacental complex
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